BIOCHEMICAL RESPONSE OF NORMAL ALBINO RATS TO THE ADDITION OF AQUEOUS LEAVES EXTRACT OF HIBISCUS CANNABINUS AND MURRAYA KOENIGII IN RATS DRINKING WATER

Authors

  • S.A. James Department of Biochemistry, Kaduna State University, Kaduna - Nigeria
  • M.J. Ladan Department of Biochemistry, Usmanu Danfodiyo University, Sokoto -Nigeria
  • R. Auta Department of Biochemistry, Kaduna State University, Kaduna - Nigeria
  • J. Audu Department of Biochemistry, Kaduna State University, Kaduna - Nigeria
  • A. Garba Department of Biochemistry, Kaduna State University, Kaduna - Nigeria

Abstract

Experiments  were  conducted  to  determine  the
biochemical  effect  of  Hibiscus  cannabinus  and  Murraya
koenigii  extracts  on  normal  albino  rats  using  standard
methods. Analyses carried out indicated that the aqueous
leaf  extract  of  H.  cannabinus  and  M.  koenigii  exhibited
significant  hypolipideamic  activity in normal rats. Results
of  phytochemical  studies  showed  that  flavonoids  and
glycosides are the major chemical constituent of the leaf
extract.  Overall  results  indicate  a  significant  (P0.05)
reduction  of  serum  cholesterol,  triglycerol  at  both
concentration  of  5  and  10  mg/Kg  b.wt.  No  significant
effect  is  seen  in  the  hematological  indices,  serum
glucose,  Aspartate  transaminase  (AST)  and  Alanine
transaminase (ALT). The significance of this study is thus
discussed.

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Published

2014-07-12

Issue

Vol. 9 No. 1 (2014)

Section

ARTICLES