THE CHEMOPREVENTIVE PROPERTIES OF ISOTHIOCYANATE ISOLATED FROM THE SEEDS OF MORINGA OLEIFERA LAM

  • R. Auta Department of Biochemistry, Kaduna State University, Kaduna,
  • P. Waziri Department of Biochemistry, Kaduna State University, Kaduna,
  • J.S. Mohammed Department of Biochemistry, Kaduna State University, Kaduna,
  • R.I. Abubakar Department of Biochemistry, Kaduna State University, Kaduna,
  • S. Wayah Department of Biochemistry, Kaduna State University, Kaduna,
  • I. Malami Department of Biochemistry, Usman Danfodio University, Sokoto,
  • B. Achi Department of Pharmacology, Kaduna State University, Kaduna,
  • Y. Alhassan Department of Biochemistry, Kaduna State University, Kaduna,

Abstract

Isothiocyanates (ITCs) are a group of plant phytochemicals believed to have numerous therapeutic properties. In the current study, Glucomoringin Isothiocyanate (GMG-ITC) was isolated and purified from the seeds of Moringa oleifera Lam. and used to treat Diethylnitrosamine-Induced Liver Cancer in rats. We observed that GMG-ITC treatment attenuated liver damage and significantly prevented the release of liver enzymes into blood plasma. In addition, the treatment significantly increased total antioxidant capacity of liver cancer induced rats that could have decreased the level of alanine amino transferase (ALT) and aspartate amino transferase (AST) in the blood. Thus, we postulate that pure isothiocyanate from the seeds of M. oleifera has potential anti-Liver Cancer activity.

Published
2020-12-31
Section
ARTICLES