Synthesis of Copper Complexes of Nicotinohydroxamic and Isonitinohydroxamic Acids
Authors
Aliyu A. O.
Department of Chemistry, Nigerian Defence Academy, Kaduna
Egwaikhide P. A.
Department of Chemistry and Centre for Biomaterials Research, University of Benin
Gimba C. E.
Department of Chemistry, ABU Zaria
Abstract
Nicotinohydroxamic acid (NHA) and isonicotinohydroxamic acid (INHA) were synthesized, characterized by electronic and spectral studies,magnetic measurements and their pKa determined spectrophotometrically as 8.68 ± 0.02 in aqueous medium of 0.1mol dm-3 I=ionic strength. The composition of the complexes was determined by Job’s plot. The ratios of Cu2+ to ligands under investigation were ML2. The formation constants obtained and the possible binding modes for the complexes in solid states are discussed. Spectral studies of the isolated complexes indicate tetragonally distorted octahedral geometry via (O,O) and (N,O) coordination modes. The magnetic moments obtained for the complexes are in the range 1.57-1.79B.M. Microbial sensitivity test carried out on the ligands and their isolated complexes showed no activity on the microorganisms under investigation.
Author Biography
Aliyu A. O., Department of Chemistry, Nigerian Defence Academy, Kaduna
Head and Senior Lecturer, Department of Biological Sciences
